We report on the realization of a Fermi-Fermi mixture of ultracold atoms that combines mass imbalance, tunability, and collisional stability. In an optically trapped sample of ^{161}Dy and ^{40}K, we identify a broad Feshbach resonance centered at a magnetic field of 217 G. Hydrodynamic expansion profiles in the resonant interaction regime reveal a bimodal behavior resulting from mass imbalance. Lifetime studies on resonance show a suppression of inelastic few-body processes by orders of magnitude, which we interpret as a consequence of the fermionic nature of our system. The resonant mixture opens up intriguing perspectives for studies on novel states of strongly correlated fermions with mass imbalance.