Hypoxia Inducible Factor-1α: The Curator of Gut Homeostasis

Abstract

The human gut microbiome is a stratified and resilient ecosystem co-inhabited by a diverse and dynamic pool of microorganisms. Microbial selection, establishment, and colonization are modulated through a complex molecular network of host-microbial interactions. These molecular bioprocesses ensure the taxonomic composition of the mature human gut microbiome. The human gut microbiome plays a vital role in host health; otherwise, any microbial dysbiosis could predispose to the onset of physiological and metabolic disorder/s. Focussed research are being carried out to identify key molecular agents defining gut homeostasis. These molecules hold the potential to develop effective therapeutic solutions for microbial dysbiosis-associated human disorders. Of these, Hypoxia-inducible factor-1α (HIF-1α) is a central player in host-microbial crosstalk to maintain gut homeostasis. Human gut microbial metabolites regulate its cellular stability, which in turn regulates various cellular processes required for the stable gut microbiome. In the present review, an effort has been made to summarize the key role of HIF-1α to maintain gut homeostasis.

Highlights: - Explain the molecular process of host microbial molecular interactions.- Establish the explicit role of HIF-1α in intestinal epithelial integrity and gut health.- Regulation of HIF-1α by human gut commensals and vice a versa.- Regulation of the host immune response for survival and colonization of human gut commensal.

Keywords: HIF-1α; SCFA; gut epithelial integrity; gut health; host microbial crosstalk; human gut microbiome; regulation of gene expression.