Structure of Supramers Formed by the Amphiphile Biotin-CMG-DOPE

Anton Zalygin; Daria Solovyeva; Ivan Vaskan; Stephen Henry; Marcel Schaefer; Pavel Volynsky; Alexander Tuzikov; Elena Korchagina; Ivan Ryzhov; Alexey Nizovtsev; Konstantin Mochalov; Roman Efremov; Eleonora Shtykova; Vladimir Oleinikov; Nicolai Bovin

doi:10.1002/open.202000139

Structure of Supramers Formed by the Amphiphile Biotin-CMG-DOPE

ChemistryOpen. 2020 Jun 2;9(6):640. doi: 10.1002/open.202000139. eCollection 2020 Jun.

Authors

Anton Zalygin¹, Daria Solovyeva¹, Ivan Vaskan^{1

2}, Stephen Henry³, Marcel Schaefer³, Pavel Volynsky¹, Alexander Tuzikov¹, Elena Korchagina¹, Ivan Ryzhov¹, Alexey Nizovtsev¹, Konstantin Mochalov¹, Roman Efremov^{1

4}, Eleonora Shtykova^{5

6}, Vladimir Oleinikov^{1

2}, Nicolai Bovin¹

Affiliations

¹ Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences 16/10 Miklukho-Maklaya str. Moscow 117997 Russia.
² National Research Nuclear University MEPhI (Moscow Engineering Physics Institute) Kashirskoe shosse 31 Moscow 115409 Russian Federation.
³ School of Engineering Computer & Mathematical Sciences Auckland University of Technology Auckland 1010 New Zealand.
⁴ National Research University Higher School of Economics Myasnitskaya Str. 20 Moscow 101000 Russian Federation.
⁵ Shubnikov Institute of Crystallography of Federal Scientific Research Centre 'Crystallography and Photonics' of Russian Academy of Sciences Moscow 119333 Russian Federation.
⁶ Semenov Institute of Chemical Physics Russian Academy of Sciences Moscow 119991 Russian Federation.

Abstract

Invited for this month's cover is the group of Prof. Nicolai Bovin from the Russian Academy of Sciences. The cover picture shows how a biotin residue initially hidden in a monolayer formed on the surface of a material by biot-CMG-DOPE (see top left) is pulled out of the layer by the streptavidin molecule (Str) that has come close to it (see below). This can be considered as a model of certain events (in particular, cis protein-ligand interactions) occurring on the surface of a living cell when it is necessary to hide the ligand from undesirable interactions, but leave the possibility of its recognition by a high-affinity protein. The picture is inspired by the legendary Yellow Submarine cartoon. Read the full text of their Full Paper at https://doi.org/10.1002/open.201900276.