Terahertz polarization sensing based on metasurface microsensor display anti-proliferation of tumor cells with aspirin

Lei Liu; Tengfei Li; Zixian Liu; Fei Fan; Hongfeng Yuan; Ziyang Zhang; Shengjiang Chang; Xiaodong Zhang

doi:10.1364/BOE.392056

Terahertz polarization sensing based on metasurface microsensor display anti-proliferation of tumor cells with aspirin

Biomed Opt Express. 2020 Apr 7;11(5):2416-2430. doi: 10.1364/BOE.392056. eCollection 2020 May 1.

Authors

Lei Liu^{1

2}, Tengfei Li^{3

2}, Zixian Liu^{1

2}, Fei Fan^{3

4}, Hongfeng Yuan¹, Ziyang Zhang³, Shengjiang Chang^{5

6}, Xiaodong Zhang^{1

7}

Affiliations

¹ Department of Cancer Research, College of Life Sciences, Nankai University, Weijin Road 94, Tianjin 300071, China.
² Contributed equally to this work.
³ Institute of Modern Optics, Nankai University, Tongyan Road 38, Tianjin 300350, China.
⁴ fanfei_gdz@126.com.
⁵ Tianjin Key Laboratory of Optoelectronic Sensor and Sensing Network Technology, Tongyan Road 38, Tianjin 300350, China.
⁶ sjchang@nankai.edu.cn.
⁷ zhangxd@nankai.edu.cn.

Abstract

The inhibition effects of aspirin on cell proliferation are investigated by both traditional THz resonance sensing and the improved THz polarization sensing method based on a polarization dependent metasurface microsensor. Compared to resonance sensing, the quality factor of polarization sensing is 4∼5 times higher than that of resonance sensing, and its figure of merit is at least one order of magnitude higher than that of the resonance sensing with the same metasurface microsensor. Our proposed metasurface-based biosensors may supply a novel viewpoint on cell proliferation from a physical perspective and be a valuable complementary reference for biological study.