Cell phone digital microscopy using an oil droplet

Biomed Opt Express. 2020 Apr 2;11(5):2328-2338. doi: 10.1364/BOE.389345. eCollection 2020 May 1.

Abstract

We introduce an accessible cell phone imaging method using small droplets of microscope immersion oil and consumer-grade oils. Oil droplets were more resistant to evaporation than water droplets, and they resolved cellular structures that were visible using a 20x/0.75 objective. We optically characterized the droplets using a cell phone screen and resolution target. We further obtained cellular resolution images of an onion epidermis and a zea stem cross-section sample. Our droplet-based method enables stable optical imaging for diagnostic and educational purposes without custom setups, specialized components, or manufacturing processes.