The heavily industrialised Kanpur region is the most polluted stretch of the Ganga river because of excessive pollutant discharge from the industries. Agricultural runoff along with climate change further adds to the pollution risk in this industrialised stretch of Ganga. In this paper, we analyse the potential impacts of climate change and land use change on the water quality in this stretch under hypothetical scenarios using the water quality model, QUAL2K. Water quality indicators of Dissolved Oxygen (DO), Biochemical Oxygen Demand, ammonia, nitrate, total nitrogen, organic-, inorganic- and total phosphorous and faecal coliform are assessed for eight climate change and six land use land cover scenarios. Eutrophic conditions are observed in this stretch of the river for all scenarios, implying severe impacts on aquatic life. DO is identified as the most sensitive indicator to the climate change scenarios considered, while nutrients and faecal coliform are more sensitive to the land use scenarios. Increase in agricultural land area leads to larger nutrient concentration while increase in built-up area causes an increase in faecal coliform concentration. Results from this hypothetical study could provide valuable guidance for improving the water quality of the Ganges in future climate change and land use change scenarios.