Hacking Human Beings with Machine Biology to Increase Lifespan

Gorka Orive; Nayere Taebnia; Itsasne Erezuma; Thomas L Andresen; Alireza Dolatshahi-Pirouz

doi:10.1016/j.tibtech.2020.05.007

Hacking Human Beings with Machine Biology to Increase Lifespan

Trends Biotechnol. 2020 Dec;38(12):1312-1315. doi: 10.1016/j.tibtech.2020.05.007. Epub 2020 Jun 1.

Authors

Gorka Orive¹, Nayere Taebnia², Itsasne Erezuma³, Thomas L Andresen², Alireza Dolatshahi-Pirouz⁴

Affiliations

¹ NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain; Biomedical Research Networking Centre in Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN), Vitoria-Gasteiz, Spain; University Institute for Regenerative Medicine and Oral Implantology - UIRMI (UPV/EHU-Fundación Eduardo Anitua), Vitoria, Spain; Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, Singapore. Electronic address: gorka.orive@ehu.eus.
² Department of Health Technology, Center for Intestinal Absorption and Transport of Biopharmaceuticals, Technical University of Denmark, 2800 Kgs, Denmark.
³ NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain.
⁴ Department of Health Technology, Center for Intestinal Absorption and Transport of Biopharmaceuticals, Technical University of Denmark, 2800 Kgs, Denmark; Department of Dentistry - Regenerative Biomaterials, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Philips van Leydenlaan 25, 6525, EX, Nijmegen, The Netherlands. Electronic address: alirezadolatshahipirouz@gmail.com.

PMID: 32499063
DOI: 10.1016/j.tibtech.2020.05.007

Abstract

Imagine a world where machines can program cells to deliver therapeutics in a remote-controlled, time-specific, and targeted manner. Or, what if physicians could collect data continuously to establish intimate links between therapy and disease progression? Such machine biology systems could empower physicians beyond imagination and give rise to personalized treatments.

Keywords: biomaterials; genetic engineering; machine biology; synthetic biology.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Humans
Longevity*
Precision Medicine* / methods
Synthetic Biology