Pyridine-2,6-Dithiocarboxylic Acid and Its Metal Complexes: New Inhibitors of New Delhi Metallo β-Lactamase-1

Mar Drugs. 2020 Jun 2;18(6):295. doi: 10.3390/md18060295.

Authors

Chris S Thomas¹, Doug R Braun¹, Jose Luis Olmos Jr², Scott R Rajski¹, George N Phillips Jr^{2

3}, David Andes⁴, Tim S Bugni¹

Affiliations

¹ Pharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, WI 53705, USA.
² Department of Biosciences, Rice University, Houston, TX 77005, USA.
³ Department of Chemistry, Rice University, Houston, TX 77005, USA.
⁴ Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.

Abstract

Keywords: NDM-1 inhibitors; marine-derived Streptomyces sp.; carbapenem-resistant Enterobacteriaceae; metal chelators.

MeSH terms

Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Coordination Complexes / chemical synthesis*
Coordination Complexes / chemistry
Coordination Complexes / pharmacology*
Meropenem / pharmacology
Microbial Sensitivity Tests
Pyridines / chemical synthesis*
Pyridines / isolation & purification
Pyridines / pharmacology*
beta-Lactamase Inhibitors / chemical synthesis*
beta-Lactamase Inhibitors / pharmacology
beta-Lactamases / chemistry
beta-Lactamases / metabolism*

Substances

Anti-Bacterial Agents
Coordination Complexes
Pyridines
beta-Lactamase Inhibitors
beta-Lactamases
beta-lactamase NDM-1
Meropenem

Grants and funding