The fibroblastic T cell niche in lymphoid tissues

Anne L Fletcher; Alfie T Baker; Veronika Lukacs-Kornek; Konstantin Knoblich

doi:10.1016/j.coi.2020.04.007

The fibroblastic T cell niche in lymphoid tissues

Curr Opin Immunol. 2020 Jun:64:110-116. doi: 10.1016/j.coi.2020.04.007. Epub 2020 Jun 1.

Authors

Anne L Fletcher¹, Alfie T Baker², Veronika Lukacs-Kornek³, Konstantin Knoblich⁴

Affiliations

¹ Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Australia; Institute of Immunology and Immunotherapy, University of Birmingham, UK. Electronic address: Anne.L.Fletcher@monash.edu.
² Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Australia.
³ Institute of Experimental Immunology, Rheinische-Friedrichs-Wilhelms University of Bonn, 53127, Bonn, Germany.
⁴ Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Australia; Institute of Immunology and Immunotherapy, University of Birmingham, UK.

PMID: 32497868
DOI: 10.1016/j.coi.2020.04.007

Abstract

Fibroblastic reticular cells (FRCs) are a necessary immunological component for T cell health. These myofibroblasts are specialized for immune cell support and develop in locations where T and B lymphocyte priming occurs, usually secondary lymphoid organs, but also tertiary lymphoid structures and sites of chronic inflammation. This review describes their dual supportive and suppressive functions and emerging evidence on the co-ordination required to balance these competing roles.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

B-Lymphocytes
Fibroblasts*
Humans
Lymphatic System
Lymphoid Tissue*
T-Lymphocytes