Critical appraisal of the International Prophylaxis Study Group magnetic resonance image scale for evaluating haemophilic arthropathy

Haemophilia. 2020 Jul;26(4):565-574. doi: 10.1111/hae.14032. Epub 2020 Jun 4.

Abstract

A goal of the International Prophylaxis Study Group (IPSG) is to provide an accurate instrument to measure MRI-based disease severity of haemophilic arthropathy at various time points, so that longitudinal changes in disease severity can be identified to support decisions on treatment management. We review and discuss in this paper the evaluative purpose of the IPSG MRI scale in relation to its development and validation processes so far. We also critically appraise the validity, reliability and responsiveness of using the IPSG MRI scale in different clinical and research settings, and whenever applicable, compare these clinimetric properties of the IPSG MRI scale with those of its precursors, the compatible additive and progressive MRI scales.

Keywords: International Prophylaxis Study Group; children; hemophilic arthropathy; joints; magnetic resonance imaging; responsiveness; validity.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Ankle Joint / diagnostic imaging
  • Ankle Joint / pathology
  • Child
  • Child, Preschool
  • Hemarthrosis / diagnosis*
  • Hemarthrosis / etiology
  • Hemarthrosis / pathology
  • Hemarthrosis / prevention & control*
  • Hemophilia A / complications
  • Hemophilia A / therapy
  • Hemosiderin / analysis
  • Humans
  • Joint Diseases / diagnostic imaging*
  • Joint Diseases / etiology
  • Knee Joint / diagnostic imaging
  • Knee Joint / pathology
  • Magnetic Resonance Imaging / methods*
  • Male
  • Observer Variation
  • Reproducibility of Results
  • Severity of Illness Index
  • Synovial Membrane / metabolism
  • Synovial Membrane / pathology

Substances

  • Hemosiderin