Long-term outcomes of adult-size and size-matched kidney transplants in small pediatric recipients

Abstract

Introduction: Adult-size kidneys are usually used for kidney transplantation in small pediatric recipients, but the influence of graft size in transplant outcome remains controversial. Our aim is to compare long-term transplant outcomes of using adult-size and size-matched kidneys in small pediatric recipients.

Materials and methods: Since 1999, 61 of 226 kidney transplants were achieved in recipients weighing <20 kg with 5 years of follow-up. Patients were analyzed according to the graft size received: (group-A) adult-size (n = 32), (group-B) size-matched (n = 29). Kidney size (KS), glomerular filtration rate (GFR) proteinuria and rejection were compared between groups at transplant time (T₀), at one (T₁), two (T₂), five years (T₅), and at the end of the follow-up (T_F) (median follow-up 8.47(0-17) years). Graft and patient survival were determined and compared between groups.

Results: Mean KS was significantly different between groups at T₀ (A:11.3 ± 1.1 cm, B:8.8 ± 0.9 cm), (pT₀<0.01), group-B evidenced graft growth, reaching similar sizes to group-A at T₅ (A:11.7±1 cm, B:11.2±1 cm; pT₅ = 0.13) and T_F (A:12.2 ± 1.1 cm, B:12.4 ± 1.2 cm; pT_F = 0.63), and group-A had a slight graft growth at T_F (pT₀-T_F<0.01). Mean Schwartz-GFR at T₀ was greater in group-A (138 ± 33 ml/min/1.73 m²) than group-B (109 ± 34 mL/min/1.73 m²) (pT₀ = 0.01); during follow-up, it evidenced a reduction in group-A (T₅:90 ± 27, T_F:71 ± 24 mL/min/1.73 m²; pT₀-T₅<0.01; pT₀-T_F<0.01), meanwhile in group-B was stable until T₅ (104 ± 33 mL/min/1.73 m²; pT₀-T₅ = 0.54), declining at T_F (76 ± 31 mL/min/1.73 m²; pT₀-T_F<0.01); with no significant differences at T₁, T₂, T₅, and TF between groups. Similar results were observed in mean Filler-GFR of both groups (Figure). Proteinuria and episodes of rejection were no significantly different between groups during the follow-up (p > 0.01; p = 0.23). Graft and patient survival at 5 and 10 years did not show significant differences (p = 0.45; p = 0.10).

Discussion: Despite the initial kidney size difference between groups, we have demonstrated that they tended to the same size during the follow-up. Adult-size kidneys presented a slight size increase in the long-term, suggesting that they have some growth potential in small recipients, in contrast to previous literature. Mean GFR between groups showed no significant differences in the long-term, suggesting that optimal graft perfusion and function can be achieved despite the size of the graft. We have demonstrated that there were no significant differences in long-term graft and patient survival; this results were similar to the most recent literature about this topic and different from the 90-2000s decades literature.

Conclusions: Adult-size kidneys may be transplanted to small recipients (<20 kg) with comparable outcomes to size-matched kidneys, with no significant differences in long-term KS, GFR, proteinuria, rejection, graft or patient survival.

Keywords: Adult-size kidney; Kidney transplant mismatch; Long-term kidney transplant outcomes; Pediatric kidney transplant; Size-matched kidney; Small pediatric recipient.