Cobbling Together the Myddosome

Michelle L D Snyder; Greg A Snyder

doi:10.1016/j.str.2020.05.006

Cobbling Together the Myddosome

Structure. 2020 Jun 2;28(6):598-600. doi: 10.1016/j.str.2020.05.006.

Authors

Michelle L D Snyder¹, Greg A Snyder²

Affiliations

¹ Towson University, Department of Biological Sciences, 8000 York Rd., Towson, MD 21212, USA.
² Institute of Human Virology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, USA. Electronic address: gsnyder@som.umaryland.edu.

PMID: 32492411
DOI: 10.1016/j.str.2020.05.006

Abstract

An organism's ability to recognize and respond quickly and appropriately to pathogenic stimuli is a fundamental aspect of innate immunity. Harnessing the dynamic nature of fluorescent microscopy and the resolution of cryo-electron microscopy, Moncrieffe et al. (2020) characterize MyD88-only filaments and provide insight into the mechanisms underlying innate immune signaling.

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MeSH terms

Adaptor Proteins, Signal Transducing
Cryoelectron Microscopy
Immunity, Innate
Myeloid Differentiation Factor 88*
Signal Transduction
Toll-Like Receptors*

Substances

Adaptor Proteins, Signal Transducing
Myeloid Differentiation Factor 88
Toll-Like Receptors