Break on Through: Golgi-Derived Vesicles Aid in Mitochondrial Fission

Megan L Rasmussen; Gabriella L Robertson; Vivian Gama

doi:10.1016/j.cmet.2020.05.010

Break on Through: Golgi-Derived Vesicles Aid in Mitochondrial Fission

Cell Metab. 2020 Jun 2;31(6):1047-1049. doi: 10.1016/j.cmet.2020.05.010.

Authors

Megan L Rasmussen¹, Gabriella L Robertson¹, Vivian Gama²

Affiliations

¹ Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
² Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA; Vanderbilt Center for Stem Cell Biology, Vanderbilt University, Nashville, TN, USA; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA. Electronic address: vivian.gama@vanderbilt.edu.

Abstract

Mitochondrial fission is sustained through contact with several organelles, including the endoplasmic reticulum, lysosomes, and the actin cytoskeleton. Nagashima et al. (2020) now demonstrate that PI(4)P-containing Golgi-derived vesicles also modulate mitochondrial fission, driven by Arf1 and PI(4)KIIIβ activity, identifying a new organelle contact involved in maintaining mitochondrial homeostasis.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Endoplasmic Reticulum / metabolism
Golgi Apparatus* / metabolism
Lysosomes / metabolism
Mitochondria
Mitochondrial Dynamics*

Abstract

Publication types

MeSH terms

Grants and funding