Mercaptopurine is a medication used in the management and treatment of acute lymphoblastic leukemia. It is in the class of medications known as purine antagonists. This activity reviews the indications, action, and contraindications for mercaptopurine as a valuable agent in treating and managing leukemias and inflammatory autoimmune disorders. This activity will highlight the mechanism of action, adverse event profile, and other key factors (e.g., off-label uses, dosing, pharmacodynamics, pharmacokinetics, monitoring, relevant interactions) pertinent for members of the healthcare team in the treatment of patients with acute lymphoblastic leukemia and some inflammatory autoimmune-related conditions.
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