Abstract
Here, a continuous two-step glass-capillary microfluidic technique to produce a multistage oral delivery system is reported. Insulin is successfully encapsulated into liposomes, which are coated with chitosan to improve their mucoadhesion. The encapsulation in an enteric polymer offers protection from the harsh gastric conditions. Insulin permeability is enhanced across an intestinal monolayer.
MeSH terms
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Administration, Oral
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Caco-2 Cells
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Chitosan / administration & dosage*
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Chitosan / chemistry
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Drug Delivery Systems*
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Drug Liberation
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HT29 Cells
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Humans
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Hydrogen-Ion Concentration
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Hypoglycemic Agents / administration & dosage*
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Hypoglycemic Agents / chemistry
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Insulin / administration & dosage*
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Insulin / chemistry
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Liposomes
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Microfluidics
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Nanoparticles / administration & dosage*
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Nanoparticles / chemistry
Substances
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Hypoglycemic Agents
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Insulin
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Liposomes
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Chitosan