Non-invasive electroencephalographical (EEG) recording system in awake monkeys

Tomoya Nakamura; Trong Ha Dinh; Makoto Asai; Hiroshi Nishimaru; Jumpei Matsumoto; Yusaku Takamura; Etsuro Hori; Sokichi Honda; Hiroshi Yamada; Takuma Mihara; Mitsuyuki Matsumoto; Hisao Nishijo

doi:10.1016/j.heliyon.2020.e04043

Non-invasive electroencephalographical (EEG) recording system in awake monkeys

Heliyon. 2020 May 27;6(5):e04043. doi: 10.1016/j.heliyon.2020.e04043. eCollection 2020 May.

Authors

Affiliations

¹ System Emotional Science, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan.
² Department of Anatomy, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan.
³ Candidate Discovery Science Labs, Drug Discovery Research, Astellas Pharma Inc., Tsukuba, Ibaraki 305-8585, Japan.

Abstract

Background: Human clinical studies reported that several electroencephalographical (EEG) parameters can be used as biomarkers of psychiatric disorders. EEGs recorded from non-human primates (monkeys) is useful for understanding of human pathologies of psychiatric disorders and development of new therapeutic agents.

New methods: In this study, we expand a previous non-invasive head holding system with face masks for awake monkeys to be applied to scalp EEG recording. The new design of a head holding system allows to attach scalp EEG electrodes on the positions comparable to human electrode placement and to present auditory stimuli.

Results: With this system, we could record auditory evoked potentials (AEPs) in auditory sensory gating and oddball paradigms, which are often used as biomarkers of psychiatric disorders in animal models and human patients. The recorded AEPs were comparable to previous human clinical data.

Comparison with existing methods: Compared with previous non-invasive head holding systems, top, side (cheek and ears), and rear of the head can be open for attachment of EEG electrodes and auditory stimulation in the present system.

Conclusions: The results suggest that the present system is useful in EEG recording from awake monkeys. Furthermore, this system can be applied to eye-tracking and chronic intra-cerebral recording experiments.

Keywords: Behavioral test; Biological psychiatry; Cognition; Consciousness; EEG; Mental disorder; Neurology; Neuroscience; Non-human primates; Non-invasive head holding; Physiology; Pre-clinical translational research; Veterinary medicine.