Immunotropic Properties of an Experimental Synthetic Selenium-Organic Compound

Bull Exp Biol Med. 2020 May;169(1):40-42. doi: 10.1007/s10517-020-04819-4. Epub 2020 Jun 2.

Abstract

We studied immunotropic properties of synthetic selenium-organic preparation 2,6-dipyridinium-9-selenabicyclo[3.3.1]nonyl dibromide (974zh). The experimental preparation reduced the cAMP/cGMP ratio, which indicated an increase in proliferative activity of cells of immunocompetent organs (thymus and spleen) in experimental animals. It was shown that 974zh intensified the immune response to Yersinia pestis EV thereby increasing the resistance to the plague agent.

Keywords: Yersinia pestis EV; cAMP; cGMP; immunity; selenium-organic preparation.

MeSH terms

  • Adjuvants, Immunologic / chemistry
  • Adjuvants, Immunologic / pharmacology
  • Adjuvants, Immunologic / therapeutic use
  • Animals
  • Combined Modality Therapy
  • Cyclic AMP / metabolism
  • Cyclic GMP / metabolism
  • Female
  • Immunity, Innate / drug effects*
  • Male
  • Mice
  • Organic Chemicals / chemistry
  • Organic Chemicals / pharmacology
  • Organic Chemicals / therapeutic use
  • Plague / drug therapy
  • Plague / immunology
  • Plague / prevention & control
  • Plague Vaccine / administration & dosage
  • Selenium / chemistry
  • Selenium / pharmacology
  • Selenium / therapeutic use
  • Selenium Compounds / chemistry
  • Selenium Compounds / pharmacology*
  • Selenium Compounds / therapeutic use
  • Spleen / drug effects
  • Spleen / immunology
  • Spleen / metabolism
  • Thymus Gland / drug effects
  • Thymus Gland / immunology
  • Thymus Gland / metabolism
  • Vaccine Potency
  • Virulence / drug effects
  • Yersinia pestis / drug effects
  • Yersinia pestis / immunology
  • Yersinia pestis / pathogenicity

Substances

  • Adjuvants, Immunologic
  • Organic Chemicals
  • Plague Vaccine
  • Selenium Compounds
  • Cyclic AMP
  • Cyclic GMP
  • Selenium