Central composite designed solid dispersion for dissolution enhancement of fluvastatin sodium by kneading technique

Ther Deliv. 2020 May;11(5):313-328. doi: 10.4155/tde-2020-0025. Epub 2020 Jun 3.

Abstract

Aim: This research is focused on enhancing aqueous solubility and dissolution of fluvastatin sodium (FSS) through solid dispersion (FSS-SD) production using polyethylene glycol 6000 and polyvinyl pyrollidone K-30 by kneading technique. Methodology & results: Central composite design explored the influence of polyethylene glycol 6000 and polyvinyl pyrollidone K-30 on T50% and Q90. The aqueous saturation solubility of FSS (8.7 ± 1.12 μg/ml) was amplified 20-fold in FSS-SD (179 ± 4.16 μg/ml). Cumulative drug release from FSS and optimized FSS-SD were 27.49 and 87.4% within 90 min, respectively. Conclusion: FSS-SD production using kneading technique offers great prospective in maximizing FSS's solubility and dissolution.

Keywords: central composite design; fluvastatin sodium; hypercholesterolemia; kneading technique; polyethylene glycol 6000; polyvinyl pyrollidone K-30.

MeSH terms

  • Drug Liberation
  • Fluvastatin
  • Polyethylene Glycols*
  • Polyvinyls*
  • Prospective Studies
  • Solubility

Substances

  • Polyvinyls
  • Polyethylene Glycols
  • Fluvastatin