An insertion-deletion polymorphism in angiotensin-converting enzyme is associated with a reduced risk of preeclampsia: an evidence-based meta-analysis from 44 studies

Ting Huang; Yu Yan; Jianxin Li; Hong Chen; Zhen Chen

doi:10.1080/10641955.2020.1769644

An insertion-deletion polymorphism in angiotensin-converting enzyme is associated with a reduced risk of preeclampsia: an evidence-based meta-analysis from 44 studies

Hypertens Pregnancy. 2020 Aug;39(3):336-347. doi: 10.1080/10641955.2020.1769644. Epub 2020 Jun 2.

Authors

Ting Huang¹, Yu Yan¹, Jianxin Li¹, Hong Chen¹, Zhen Chen¹

Affiliation

¹ Department of Obstetrics, Chongqing Health Center for Women and Children , Chongqing, P.R. China.

PMID: 32484368
DOI: 10.1080/10641955.2020.1769644

Abstract

Objective An updated meta-analysis was performed to evaluate the relationship between an insertion/deletion (I/D) polymorphism in angiotensin-converting enzyme (ACE) and preeclampsia (PE) risk. Methods Pubmed, OVID and China National Knowledge Infrastructure databases were searched. Pooled odds ratios with 95% confidence intervals were calculated using fixed-effects or random-effects model. Results ACE I/D polymorphism decreased the risk of PE in overall analysis. Subgroup analysis revealed a significantly lower risk of PE with ACE I/D polymorphism in Asians, Caucasians. The decreased risk was also found in severe PE and early-onset PE. Conclusion ACE I/D polymorphism may protect against the development of PE.

Keywords: Angiotensin-converting enzyme; meta-analysis; polymorphism; preeclampsia.

Publication types

Meta-Analysis

MeSH terms

Female
Genetic Predisposition to Disease*
Humans
INDEL Mutation*
Peptidyl-Dipeptidase A / genetics*
Polymorphism, Genetic
Pre-Eclampsia / genetics*
Pregnancy

Substances

Peptidyl-Dipeptidase A