Validity of the McDonald criteria in predicting second events in multiple sclerosis

Kejia Zhang; Yinlong Zhao; Zhenzhen Liang; Chunpeng Wang; Xin Liu

doi:10.1016/j.msard.2020.102223

Validity of the McDonald criteria in predicting second events in multiple sclerosis

Mult Scler Relat Disord. 2020 Aug:43:102223. doi: 10.1016/j.msard.2020.102223. Epub 2020 May 25.

Authors

Kejia Zhang¹, Yinlong Zhao², Zhenzhen Liang³, Chunpeng Wang⁴, Xin Liu⁵

Affiliations

¹ Stroke Center, Department of Neurology, the First Hospital of Jilin University, Chang Chun, Jilin, China.
² Dept. Nuclear Medicine, 2nd Hospital, Jilin University, Changchun, China.
³ NHC Key Lab of Radiobiology (Jilin University), Changchun, Jilin 130021, China.
⁴ School of Mathematics and Statistics, Northeast Normal University, Changchun, Jilin 130000, China.
⁵ Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, Jilin 130021, China. Electronic address: liuxin2015722010@163.com.

PMID: 32480348
DOI: 10.1016/j.msard.2020.102223

Abstract

Background: The McDonald criteria are designed for predicting the second event in multiple sclerosis. With several revisions made to the McDonald criteria, the criteria get much easier to use, but what about the diagnostic validity? This research is conducted for evaluating the diagnostic validity of the McDonald criteria in multiple sclerosis.

Methods: Pubmed, Web of Science, Cochrane Library were systematically searched with keywords of "Multiple sclerosis" and "McDonald criteria" from, January 1^st, 2010 to 27^th, February 2020. The methodological quality of each study is assessed by Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). All of the statistics are analyzed by software STATA 12.0 and Meta-Disc 1.4.

Results: Twenty articles are finally included according to the inclusion and exclusion criteria. Both the 2010 and 2017 McDonald criteria have excellent performance in predicting second events in multiple sclerosis. The 2017 McDonald criteria have better performance compared to the 2010 McDonald criteria (AUC, 0.83 vs 0.77). It is increased in sensitivity but decreased in specificity.

Conclusion: The McDonald criteria are useful in predicting second events in multiple sclerosis. The 2017 McDonald criteria have better performance than the 2010 McDonald criteria with increased sensitivity but decreased specificity.

Keywords: Diagnosis; Mcdonald criteria; Mri criteria; Multiple sclerosis.

Publication types

Review

MeSH terms

Humans
Magnetic Resonance Imaging
Multiple Sclerosis* / diagnosis
Sensitivity and Specificity