Curcumin-loaded lipid-core nanocapsules attenuates the immune challenge LPS-induced in rats: Neuroinflammatory and behavioral response in sickness behavior

J Neuroimmunol. 2020 Aug 15:345:577270. doi: 10.1016/j.jneuroim.2020.577270. Epub 2020 May 23.

Abstract

The purpose of current study was to evaluate the effect of curcumin (CUR) loaded lipid-core nanocapsules (CUR-LNC) treatment on neuroinflammatory and behavioral alterations in a model of sickness behavior induced by lipopolysaccharide (LPS) in rats. Rats were treated with CUR-LNC and CUR daily for 14 days. After the last treatments, sickness behavior was induced with LPS. Sickness behavior LPS-induced was confirmed by behavioral tests, an increase in levels of proinflammatory cytokines, decrease in levels of IL-10, overexpression of IDO-1 and IDO-2. In conclusion, CUR-LNC treatment attenuated the neuroinflammatory and behavioral changes caused in sickness behavior model.

Keywords: Antidepressant; IL-10; Nanocapsules; Neuroimmunomodulatory.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Curcumin / administration & dosage*
  • Drug Carriers / administration & dosage
  • Illness Behavior / drug effects
  • Illness Behavior / physiology*
  • Inflammation Mediators / antagonists & inhibitors
  • Inflammation Mediators / immunology*
  • Inflammation Mediators / metabolism
  • Lipids
  • Lipopolysaccharides / toxicity*
  • Locomotion / drug effects
  • Locomotion / physiology*
  • Male
  • Nanocapsules / administration & dosage*
  • Rats
  • Rats, Wistar

Substances

  • Drug Carriers
  • Inflammation Mediators
  • Lipids
  • Lipopolysaccharides
  • Nanocapsules
  • Curcumin