SARS-CoV-2 entry in host cells-multiple targets for treatment and prevention

Ismail Sami Mahmoud; Yazun Bashir Jarrar; Walhan Alshaer; Said Ismail

doi:10.1016/j.biochi.2020.05.012

SARS-CoV-2 entry in host cells-multiple targets for treatment and prevention

Biochimie. 2020 Aug:175:93-98. doi: 10.1016/j.biochi.2020.05.012. Epub 2020 May 29.

Authors

Ismail Sami Mahmoud¹, Yazun Bashir Jarrar², Walhan Alshaer³, Said Ismail⁴

Affiliations

¹ Department of Medical Laboratory Sciences, The Hashemite University, Zarqa, 13133, Jordan. Electronic address: ismails@hu.edu.jo.
² Department of Pharmacy, Alzaytoonah University of Jordan, Amman, Jordan.
³ Cell Therapy Center, The University of Jordan, Amman, 11942, Jordan.
⁴ Faculty of Medicine, The University of Jordan, Amman, 11942, Jordan; Qatar Genome Project, Qatar Foundation, Doha, Qatar.

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new viral disease that has gained global attention owing to its ability to provoke community and health-care-associated outbreaks of severe infections in human populations. The virus poses serious challenges to clinical management because there are still no approved anti- SARS-CoV-2 drugs available. In this mini-review, we summarize the much updated published reports that demonstrate the mechanism of SARS-CoV-2 entry into host cells, and discuss the availability and development of attractive host-based therapeutic options for SARS-CoV-2 infections.

Keywords: ACE2; Drugs; Entry; Proteases; SARS-CoV-2.

Publication types

Review

MeSH terms

Betacoronavirus / metabolism*
Betacoronavirus / pathogenicity*
COVID-19
Coronavirus Infections / metabolism*
Coronavirus Infections / therapy
Host-Pathogen Interactions / physiology*
Humans
Pandemics
Pneumonia, Viral / metabolism*
Pneumonia, Viral / therapy
SARS-CoV-2
Virus Internalization*