Impact of COVID-19 pandemic on ST-elevation myocardial infarction in a non-COVID-19 epicenter

Catheter Cardiovasc Interv. 2021 Feb 1;97(2):208-214. doi: 10.1002/ccd.28997. Epub 2020 Jun 1.

Abstract

Objectives: We sought to study the impact of COVID-19 pandemic on the presentation delay, severity, patterns of care, and reasons for delay among patients with ST-elevation myocardial infarction (STEMI) in a non-hot-spot region.

Background: COVID-19 pandemic has significantly reduced the activations for STEMI in epicenters like Spain.

Methods: From January 1, 2020, to April 15, 2020, 143 STEMIs were identified across our integrated 18-hospital system. Pre- and post-COVID-19 cohorts were based on March 23rd, 2020, whenstay-at-home orders were initiated in Ohio. We used presenting heart rate, blood pressure, troponin, new Q-wave, and left ventricle ejection fraction (LVEF) to assess severity. Duration of intensive care unit stay, total length of stay, door-to-balloon (D2B) time, and radial versus femoral access were used to assess patterns of care.

Results: Post-COVID-19 presentation was associated with a lower admission LVEF (45 vs. 50%, p = .015), new Q-wave, and higher initial troponin; however, these did not reach statistical significance. Among post-COVID-19 patients, those with >12-hr delay in presentation 31(%) had a longer average D2B time (88 vs. 53 min, p = .033) and higher peak troponin (58 vs. 8.5 ng/ml, p = .03). Of these, 27% avoided the hospital due to fear of COVID-19, 18% believed symptoms were COVID-19 related, and 9% did not want to burden the hospital during the pandemic.

Conclusions: COVID-19 has remarkably affected STEMI presentation and care. Patients' fear and confusion about symptoms are integral parts of this emerging public health crisis.

Keywords: coronavirus; delayed presentation; door-to-balloon; length of stay; troponin.

MeSH terms

  • Aged
  • COVID-19 / epidemiology*
  • Communicable Disease Control
  • Female
  • Humans
  • Length of Stay
  • Male
  • Middle Aged
  • Ohio
  • Retrospective Studies
  • ST Elevation Myocardial Infarction / diagnosis*
  • ST Elevation Myocardial Infarction / mortality
  • ST Elevation Myocardial Infarction / therapy*
  • Survival Rate
  • Time-to-Treatment
  • Treatment Outcome