Nanoparticle-mediated double-stranded RNA delivery system: A promising approach for sustainable pest management

Shuo Yan; Bin-Yuan Ren; Jie Shen

doi:10.1111/1744-7917.12822

Nanoparticle-mediated double-stranded RNA delivery system: A promising approach for sustainable pest management

Insect Sci. 2021 Feb;28(1):21-34. doi: 10.1111/1744-7917.12822. Epub 2020 Jul 20.

Authors

Shuo Yan¹, Bin-Yuan Ren², Jie Shen¹

Affiliations

¹ Department of Entomology and MOA Key Lab of Pest Monitoring and Green Management, College of Plant Protection, China Agricultural University, Beijing, China.
² National Agricultural Technology Extension and Service Center, Beijing, China.

PMID: 32478473
DOI: 10.1111/1744-7917.12822

Abstract

RNA interference (RNAi) targeting lethal genes in insects has great potential for sustainable crop protection. Compared with traditional double-stranded (ds)RNA delivery systems, nanoparticles such as chitosan, liposomes, and cationic dendrimers offer advantages in delivering dsRNA/small interfering (si)RNA to improve RNAi efficiency, thus promoting the development and practice of RNAi-based pest management strategies. Here, we illustrate the limitations of traditional dsRNA delivery systems, reveal the mechanism of nanoparticle-mediated RNAi, summarize the recent progress and successful applications of nanoparticle-mediated RNAi in pest management, and finally address the prospects of nanoparticle-based RNA pesticides.

Keywords: RNA pesticide; RNAi efficiency; dsRNA delivery; nanocarrier; pest control.

Publication types

Review

MeSH terms

Animals
Insect Control / methods*
Insecta*
Nanoparticles / analysis*
RNA Interference*
RNA, Double-Stranded / administration & dosage*
RNA, Small Interfering / analysis*

Substances

RNA, Double-Stranded
RNA, Small Interfering

Abstract

Publication types

MeSH terms

Substances

Grants and funding