Abstract
Nanoparticle-cell-nanoparticle communication by stigmergy was demonstrated using two capped nanodevices. The first community of nanoparticles (i.e.S(RA)IFN) is loaded with 9-cis-retinoic acid and capped with interferon-γ, whereas the second community of nanoparticles (i.e.S(sulf)PIC) is loaded with sulforhodamine B and capped with poly(I:C). The uptake of S(RA)IFN by SK-BR-3 breast cancer cells enhanced the expression of TLR3 receptor facilitating the subsequent uptake of S(sulf)PIC and cell killing.
MeSH terms
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Alitretinoin / chemistry
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / metabolism*
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Apoptosis / drug effects
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Cell Communication / drug effects*
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Cell Line, Tumor
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Gene Expression Regulation / drug effects
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Humans
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Interferon Inducers / chemistry
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Interferon Inducers / metabolism*
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Interferon-gamma / drug effects
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Nanoparticles / chemistry*
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Nanoparticles / metabolism
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Poly I-C / chemistry
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Poly I-C / metabolism*
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Rhodamines / chemistry
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Toll-Like Receptor 3 / genetics
Substances
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Antineoplastic Agents
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Interferon Inducers
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Rhodamines
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Toll-Like Receptor 3
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Alitretinoin
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lissamine rhodamine B
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Interferon-gamma
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Poly I-C