Nanoparticle-cell-nanoparticle communication by stigmergy to enhance poly(I:C) induced apoptosis in cancer cells

Chem Commun (Camb). 2020 Jul 2;56(53):7273-7276. doi: 10.1039/d0cc02795b.

Abstract

Nanoparticle-cell-nanoparticle communication by stigmergy was demonstrated using two capped nanodevices. The first community of nanoparticles (i.e.S(RA)IFN) is loaded with 9-cis-retinoic acid and capped with interferon-γ, whereas the second community of nanoparticles (i.e.S(sulf)PIC) is loaded with sulforhodamine B and capped with poly(I:C). The uptake of S(RA)IFN by SK-BR-3 breast cancer cells enhanced the expression of TLR3 receptor facilitating the subsequent uptake of S(sulf)PIC and cell killing.

MeSH terms

  • Alitretinoin / chemistry
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / metabolism*
  • Apoptosis / drug effects
  • Cell Communication / drug effects*
  • Cell Line, Tumor
  • Gene Expression Regulation / drug effects
  • Humans
  • Interferon Inducers / chemistry
  • Interferon Inducers / metabolism*
  • Interferon-gamma / drug effects
  • Nanoparticles / chemistry*
  • Nanoparticles / metabolism
  • Poly I-C / chemistry
  • Poly I-C / metabolism*
  • Rhodamines / chemistry
  • Toll-Like Receptor 3 / genetics

Substances

  • Antineoplastic Agents
  • Interferon Inducers
  • Rhodamines
  • Toll-Like Receptor 3
  • Alitretinoin
  • lissamine rhodamine B
  • Interferon-gamma
  • Poly I-C