The Telomeric Cdc13 Protein from Yeast Hansenula polymorpha

A N Malyavko; O A Dontsova

doi:10.32607/actanaturae.10944

The Telomeric Cdc13 Protein from Yeast Hansenula polymorpha

Acta Naturae. 2020 Jan-Mar;12(1):84-88. doi: 10.32607/actanaturae.10944.

Authors

A N Malyavko¹, O A Dontsova^{1

2

3}

Affiliations

¹ Faculty of Chemistry and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119991 Russia.
² Skolkovo Institute of Science and Technology, Moscow, 121205 Russia.
³ Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, 117997 Russia.

Abstract

Telomeres are special structures at the ends of chromosomes that play an important role in the protection of the genetic material. Telomere composition is very diverse; noticeable differences can often be observed even among closely related species. Here, we identify the homolog of telomeric protein Cdc13 in the thermotolerant yeast Hansenula polymorpha. We show that it can specifically bind single-stranded telomeric DNA, as well as interact with the Stn1 protein. In addition, we have uncovered an interaction between Cdc13 and TERT (one of the core components of the telomerase complex), which suggests that Cdc13 is potentially involved in telomerase recruitment to telomeres in H. polymorpha.

Keywords: Cdc13; telomerase; telomeres.