N,O-Benzamide difluoroboron complexes as near-infrared probes for the detection of β-amyloid and tau fibrils

Chem Commun (Camb). 2020 Jul 2;56(53):7269-7272. doi: 10.1039/d0cc02820g.

Abstract

In this study, a series of organo difluoroboron probes with a BF2 benzamide moiety was designed, prepared and evaluated. Among them, 2c displayed the best optical and biological properties, and may be used as a useful near-infrared fluorescent probe for the detection of Aβ plaques and neurofibrillary tangles in AD.

MeSH terms

  • Aged, 80 and over
  • Alzheimer Disease / diagnosis*
  • Amyloid beta-Peptides / analysis*
  • Animals
  • Benzamides / chemistry*
  • Biological Transport
  • Biosensing Techniques
  • Boron Compounds / chemistry*
  • Boron Compounds / metabolism
  • Disease Models, Animal
  • Female
  • Fluorescent Dyes / chemistry*
  • Fluorescent Dyes / metabolism
  • Hippocampus / diagnostic imaging
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Male
  • Mice
  • Optical Imaging
  • Presenilin-1 / analysis
  • Protein Binding
  • Protein Conformation
  • Spectrometry, Fluorescence
  • Spectroscopy, Near-Infrared
  • tau Proteins / analysis*

Substances

  • 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
  • Amyloid beta-Peptides
  • Benzamides
  • Boron Compounds
  • Fluorescent Dyes
  • Presenilin-1
  • tau Proteins