Abstract
In this study, a series of organo difluoroboron probes with a BF2 benzamide moiety was designed, prepared and evaluated. Among them, 2c displayed the best optical and biological properties, and may be used as a useful near-infrared fluorescent probe for the detection of Aβ plaques and neurofibrillary tangles in AD.
MeSH terms
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Aged, 80 and over
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Alzheimer Disease / diagnosis*
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Amyloid beta-Peptides / analysis*
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Animals
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Benzamides / chemistry*
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Biological Transport
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Biosensing Techniques
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Boron Compounds / chemistry*
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Boron Compounds / metabolism
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Disease Models, Animal
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Female
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Fluorescent Dyes / chemistry*
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Fluorescent Dyes / metabolism
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Hippocampus / diagnostic imaging
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Humans
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Hydrophobic and Hydrophilic Interactions
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Male
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Mice
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Optical Imaging
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Presenilin-1 / analysis
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Protein Binding
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Protein Conformation
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Spectrometry, Fluorescence
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Spectroscopy, Near-Infrared
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tau Proteins / analysis*
Substances
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4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
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Amyloid beta-Peptides
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Benzamides
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Boron Compounds
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Fluorescent Dyes
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Presenilin-1
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tau Proteins