Core-shell pea protein-carboxymethylated corn fiber gum composite nanoparticles as delivery vehicles for curcumin

Yue Wei; Zhixiang Cai; Min Wu; Yalong Guo; Pengguang Wang; Ruiqi Li; Aiqin Ma; Hongbin Zhang

doi:10.1016/j.carbpol.2020.116273

Core-shell pea protein-carboxymethylated corn fiber gum composite nanoparticles as delivery vehicles for curcumin

Carbohydr Polym. 2020 Jul 15:240:116273. doi: 10.1016/j.carbpol.2020.116273. Epub 2020 Apr 14.

Authors

Yue Wei¹, Zhixiang Cai¹, Min Wu¹, Yalong Guo¹, Pengguang Wang¹, Ruiqi Li¹, Aiqin Ma², Hongbin Zhang³

Affiliations

¹ Department of Polymer Science and Engineering, School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory of Electrical Insulation and Thermal Aging, Shanghai Jiao Tong University, Shanghai, 200240, China.
² Affiliated Sixth People's Hospital South Campus, Shanghai Jiao Tong University, 6600 Nanfeng Road, Fengxian District, Shanghai, 201499, China.
³ Department of Polymer Science and Engineering, School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory of Electrical Insulation and Thermal Aging, Shanghai Jiao Tong University, Shanghai, 200240, China. Electronic address: hbzhang@sjtu.edu.cn.

PMID: 32475561
DOI: 10.1016/j.carbpol.2020.116273

Abstract

Nanocomposites from plant-derived polysaccharides and proteins are green and sustainable materials that can be applied in various food and biomedical fields. In this work, we developed a novel core-shell nanocomposite from carboxymethylated corn fiber gum (CMCFG) and high nutritious pea protein (PP) for curcumin (Cur) delivery. In the preparation, PP-Cur complexes (PP-Cur) were formed at pH 7.0 and then coated by CMCFG via hydrophobic interactions to form PP-Cur-CMCFG complexes. Furthermore, the interactions between CMCFG and PP-Cur in the complexes were enhanced at pH 3.5 by electrostatic interactions. The resulting nanocomposite exhibited an excellent encapsulation performance for Cur with high Cur loading efficiency, good water dispersibility, and high chemical and thermal stability. Besides, the Cur-loaded core-shell nanocomposite also showed higher antioxidant and radical scavenging activities than Cur. Our results provide support for the use of plant-derived delivery systems as a strategy for the delivery of chemically unstable hydrophobic Cur.

Keywords: core-shell nanoparticles; curcumin; drug delivery; pea protein; polysaccharide.

MeSH terms

Antioxidants / chemistry*
Curcumin / chemistry*
Drug Carriers / chemistry*
Drug Liberation
Nanocomposites / chemistry*
Pea Proteins / chemistry*
Plant Gums / chemistry*
Zea mays*

Substances

Antioxidants
Drug Carriers
Pea Proteins
Plant Gums
Curcumin