Role of nitroxyl (HNO) in cardiovascular system: From biochemistry to pharmacology

Pharmacol Res. 2020 Sep:159:104961. doi: 10.1016/j.phrs.2020.104961. Epub 2020 May 29.

Abstract

Cardiovascular diseases are recognized to be a major cause of people morbidity and mortality. A host of stress signals contribute to the pathogenesis of cardiovascular disorders. Deficiency of hydrogen sulfide (H2S) or nitric oxide (NO) coordinately plays essential roles in the development of cardiovascular diseases. Recent studies have shown that interaction between the two gaseostransmitters, H2S and NO, may give rise to nitroxyl (HNO), one-electron-reduced product of NO. HNO is found to exhibit a variety of biological and pharmacological properties including positive inotropy and cardiovascular protective effects, etc. In this review, recent progresses regarding HNO generation, detection, biochemical and pharmacological functions are discussed.

Keywords: Cardiovascular diseases; Hydrogen sulfide; Nitric oxide; Nitroxyl.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cardiovascular Agents / adverse effects
  • Cardiovascular Agents / therapeutic use*
  • Cardiovascular Diseases / drug therapy*
  • Cardiovascular Diseases / metabolism
  • Cardiovascular Diseases / physiopathology
  • Cardiovascular System / drug effects*
  • Cardiovascular System / metabolism
  • Cardiovascular System / physiopathology
  • Humans
  • Hydrogen Sulfide / metabolism
  • Nitric Oxide / metabolism
  • Nitric Oxide Donors / therapeutic use
  • Nitrogen Oxides / adverse effects
  • Nitrogen Oxides / metabolism
  • Nitrogen Oxides / therapeutic use*

Substances

  • Cardiovascular Agents
  • Nitric Oxide Donors
  • Nitrogen Oxides
  • Nitric Oxide
  • nitroxyl
  • Hydrogen Sulfide