Abstract
Atropa belladonna L. (Solanaceae) tincture was compared with atropine for its anticholinergic activity, both in vivo and in vitro. In all tests, the biological activity of A. belladonna resulted greater than that suggested by its alkaloid content. The results suggest the presence in A. belladonna leaves of unknown compounds with a significant biological activity.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / pharmacology
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Animals
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Atropa belladonna*
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Atropine / antagonists & inhibitors
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Atropine / pharmacology*
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Atropine / toxicity
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Autonomic Agents / antagonists & inhibitors
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Autonomic Agents / pharmacology*
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Autonomic Agents / toxicity
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Behavior, Animal / drug effects*
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Drug Evaluation, Preclinical
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Female
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Guinea Pigs
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In Vitro Techniques
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Lethal Dose 50
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Male
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Mice
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Mice, Inbred Strains
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Oxotremorine / pharmacology
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Parasympatholytics / antagonists & inhibitors
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Parasympatholytics / pharmacology
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Parasympatholytics / toxicity
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Plant Extracts / pharmacology
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Plants, Medicinal*
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Plants, Toxic*
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Scopolamine / antagonists & inhibitors
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Scopolamine / pharmacology
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Scopolamine / toxicity
Substances
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Alkaloids
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Autonomic Agents
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Parasympatholytics
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Plant Extracts
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Oxotremorine
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Atropine
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Scopolamine