Two novel milbemycin derivatives from the genetically engineered strain Streptomyces avermitilis AVE-H39

J Antibiot (Tokyo). 2020 Sep;73(9):642-645. doi: 10.1038/s41429-020-0317-2. Epub 2020 May 29.

Abstract

Two novel milbemycin derivatives, 5,27-epoxy-13α-hydroxy milbemycin β11 (1) and 5,27-epoxy-13α-hydroxy-25-ethyl milbemycin β11 (2), were isolated from the genetically engineered strain Streptomyces avermitilis AVE-H39. Their structures were elucidated through the interpretation of HR-ESIMS and extensive NMR spectroscopic data. Compounds 1 and 2 exhibited moderate acaricidal and nematicidal activities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acaricides / chemistry
  • Acaricides / pharmacology
  • Antinematodal Agents / chemistry*
  • Antinematodal Agents / pharmacology*
  • Genetic Engineering / methods
  • Macrolides / chemistry*
  • Macrolides / pharmacology*
  • Magnetic Resonance Spectroscopy / methods
  • Molecular Structure
  • Streptomyces / metabolism*

Substances

  • Acaricides
  • Antinematodal Agents
  • Macrolides
  • moxidectin

Supplementary concepts

  • Streptomyces avermitilis