Abstract
Two novel milbemycin derivatives, 5,27-epoxy-13α-hydroxy milbemycin β11 (1) and 5,27-epoxy-13α-hydroxy-25-ethyl milbemycin β11 (2), were isolated from the genetically engineered strain Streptomyces avermitilis AVE-H39. Their structures were elucidated through the interpretation of HR-ESIMS and extensive NMR spectroscopic data. Compounds 1 and 2 exhibited moderate acaricidal and nematicidal activities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acaricides / chemistry
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Acaricides / pharmacology
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Antinematodal Agents / chemistry*
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Antinematodal Agents / pharmacology*
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Genetic Engineering / methods
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Macrolides / chemistry*
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Macrolides / pharmacology*
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Magnetic Resonance Spectroscopy / methods
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Molecular Structure
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Streptomyces / metabolism*
Substances
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Acaricides
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Antinematodal Agents
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Macrolides
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moxidectin