Acute Hyperglycemia and Spatial Working Memory in Adolescents With Type 1 Diabetes

Diabetes Care. 2020 Aug;43(8):1941-1944. doi: 10.2337/dc20-0171. Epub 2020 May 29.

Abstract

Objective: To investigate the effect of acute hyperglycemia on brain function in adolescents with type 1 diabetes (T1D).

Research design and methods: Twenty participants with T1D (aged 14.64 ± 1.78 years) and 20 age-matched healthy control subjects (aged 14.40 ± 2.82 years) performed two functional MRI sessions. Participants with T1D performed the first scanning session under euglycemic and the second under hyperglycemic clamp (20 mmol/L [360 mg/dL]).

Results: Lower spatial working memory (sWM) capacity during acute hyperglycemia and significant differences in activation of regions of interest during different stages of the sWM task (P = 0.014) were observed.

Conclusions: Acute hyperglycemia negatively affected sWM capacity in adolescents with T1D, which is relevant for daily functioning and academic performance.

Trial registration: ClinicalTrials.gov NCT03188757.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Adolescent
  • Case-Control Studies
  • Child
  • Diabetes Mellitus, Type 1 / complications
  • Diabetes Mellitus, Type 1 / diagnostic imaging
  • Diabetes Mellitus, Type 1 / physiopathology
  • Diabetes Mellitus, Type 1 / psychology*
  • Female
  • Glucose Clamp Technique
  • Humans
  • Hyperglycemia / diagnostic imaging
  • Hyperglycemia / physiopathology
  • Hyperglycemia / psychology*
  • Magnetic Resonance Imaging
  • Male
  • Memory, Short-Term / physiology*
  • Spatial Memory / physiology*
  • Young Adult

Associated data

  • figshare/10.2337/figshare.12152181
  • ClinicalTrials.gov/NCT03188757