Abstract
Contrast-induced acute kidney injury (CI-AKI) is a common complication after intravascular injection of iodinated contrast media, and it is associated with a prolonged in-hospital stay and unfavorable outcome. CI-AKI occurs in 5% to 20% among hospitalized patients. Its diagnosis relies on the increase in serum creatinine levels, which is a late biomarker of kidney injury. Novel and early serum and urinary biomarkers have been identified to detect kidney damage before the expected serum creatinine increase.
Keywords:
Acute kidney injury; Biomarker; Contrast media; Contrast nephropathy.
Copyright © 2020 Elsevier Inc. All rights reserved.
MeSH terms
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Acetylglucosaminidase / urine
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Acute Kidney Injury / chemically induced*
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Acute Kidney Injury / diagnosis
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Acute Kidney Injury / metabolism*
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Acute Kidney Injury / physiopathology
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Adaptor Proteins, Signal Transducing / urine
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Albuminuria / diagnosis
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Biomarkers / blood*
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Biomarkers / urine*
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Contrast Media / administration & dosage
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Contrast Media / adverse effects*
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Creatinine / blood
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Cystatin C / blood
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Fatty Acid-Binding Proteins / urine
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Female
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Hepatitis A Virus Cellular Receptor 1 / metabolism
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Humans
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Interleukin-18 / urine
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Length of Stay / statistics & numerical data*
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Lipocalin-2 / urine
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Male
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Midkine / blood
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Retinol-Binding Proteins / urine
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beta 2-Microglobulin / blood
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beta 2-Microglobulin / urine
Substances
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Adaptor Proteins, Signal Transducing
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Biomarkers
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Contrast Media
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Cystatin C
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DKK3 protein, human
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FABP1 protein, human
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Fatty Acid-Binding Proteins
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HAVCR1 protein, human
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Hepatitis A Virus Cellular Receptor 1
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Interleukin-18
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Lipocalin-2
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Retinol-Binding Proteins
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beta 2-Microglobulin
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Midkine
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Creatinine
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Acetylglucosaminidase