A Comprehensive Updated Review on SARS-CoV-2 and COVID-19

Yunzhao R Ren; Amit Golding; Alfred Sorbello; Ping Ji; Jianmeng Chen; Bhawana Saluja; Kimberly Witzmann; Vikram Arya; Kellie S Reynolds; Su-Young Choi; Nikolay P Nikolov; Chandrahas Sahajwalla

doi:10.1002/jcph.1673

A Comprehensive Updated Review on SARS-CoV-2 and COVID-19

J Clin Pharmacol. 2020 Aug;60(8):954-975. doi: 10.1002/jcph.1673. Epub 2020 Jun 24.

Authors

Affiliations

¹ Division of Inflammation and Immune Pharmacology, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, FDA, Silver Spring, Maryland, USA.
² Division of Rheumatology and Transplant Medicine, Office of Immunology and Inflammation, Office of New Drugs, Center for Drug Evaluation and Research, FDA, Silver Spring, Maryland, USA.
³ Office of Translational Sciences, Center for Drug Evaluation and Research, FDA, Silver Spring, Maryland, USA.
⁴ Office of Bioequivalence, Office of Generic Drugs, Center for Drug Evaluation and Research, FDA, Silver Spring, Maryland, USA.
⁵ Division of Infectious Disease Pharmacology, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, FDA, Silver Spring, Maryland, USA.

Abstract

This literature review aims to provide a comprehensive current summary of the pathogenesis, clinical features, disease course, host immune responses, and current investigational antiviral and immunomodulatory pharmacotherapies to facilitate the development of future therapies and measures for prevention and control.

Keywords: COVID-19; SARS-CoV-2; clinical characteristics; review; treatment.

Published 2020. This article is a U.S. Government work and is in the public domain in the USA.

Publication types

Review

MeSH terms

Antiviral Agents / therapeutic use*
Betacoronavirus / drug effects*
Betacoronavirus / immunology
COVID-19
COVID-19 Drug Treatment
Coronavirus Infections / drug therapy*
Coronavirus Infections / immunology
Coronavirus Infections / pathology
Coronavirus Infections / prevention & control
Humans
Immunotherapy / methods*
Pandemics / prevention & control
Pneumonia, Viral / drug therapy*
Pneumonia, Viral / immunology
Pneumonia, Viral / pathology
Pneumonia, Viral / prevention & control
SARS-CoV-2

Substances

Antiviral Agents