Artificial intelligence radiogenomics for advancing precision and effectiveness in oncologic care (Review)

Int J Oncol. 2020 Jul;57(1):43-53. doi: 10.3892/ijo.2020.5063. Epub 2020 May 11.

Abstract

The new era of artificial intelligence (AI) has introduced revolutionary data‑driven analysis paradigms that have led to significant advancements in information processing techniques in the context of clinical decision‑support systems. These advances have created unprecedented momentum in computational medical imaging applications and have given rise to new precision medicine research areas. Radiogenomics is a novel research field focusing on establishing associations between radiological features and genomic or molecular expression in order to shed light on the underlying disease mechanisms and enhance diagnostic procedures towards personalized medicine. The aim of the current review was to elucidate recent advances in radiogenomics research, focusing on deep learning with emphasis on radiology and oncology applications. The main deep learning radiogenomics architectures, together with the clinical questions addressed, and the achieved genetic or molecular correlations are presented, while a performance comparison of the proposed methodologies is conducted. Finally, current limitations, potentially understudied topics and future research directions are discussed.

Keywords: medical imaging/radiogenomics; artificial intelligence; deep learning; machine learning; precision medicine; oncology.

Publication types

  • Review

MeSH terms

  • Artificial Intelligence*
  • Biomarkers, Tumor / genetics
  • Decision Support Systems, Clinical
  • Deep Learning
  • Humans
  • Image Processing, Computer-Assisted
  • Imaging Genomics* / trends
  • Neoplasms / diagnostic imaging
  • Neoplasms / genetics
  • Precision Medicine* / trends
  • Radiation Oncology* / trends

Substances

  • Biomarkers, Tumor