Multiplex Spatial Bioimaging for Combination Therapy Design

Shuangyi Cai; Mayar Allam; Ahmet F Coskun

doi:10.1016/j.trecan.2020.05.003

Multiplex Spatial Bioimaging for Combination Therapy Design

Trends Cancer. 2020 Oct;6(10):813-818. doi: 10.1016/j.trecan.2020.05.003. Epub 2020 May 25.

Authors

Shuangyi Cai¹, Mayar Allam¹, Ahmet F Coskun²

Affiliations

¹ Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
² Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA; Interdisciplinary Program in Bioengineering, Georgia Institute of Technology, Atlanta, GA, USA. Electronic address: ahmet.coskun@bme.gatech.edu.

PMID: 32466969
DOI: 10.1016/j.trecan.2020.05.003

Abstract

Multiplex spatial analyses dissect the heterogeneous cellular abundances and interactions in tumors. Single-cell bioimaging profiles many disease-associated protein biomarkers in patient biopsies to inform the design of cancer therapies. Guided by the mechanistic insights from spatial cellular maps, combination therapy can efficiently eliminate cancers with reduced off-targets, resistance, and relapse.

Keywords: cell interactions; combination therapy; multiplex; single-cell analysis; spatial omics.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Biomarkers, Tumor / analysis
Combined Modality Therapy
Diagnostic Imaging / methods*
Humans
Neoplasms / diagnostic imaging*
Neoplasms / metabolism
Neoplasms / therapy
Single-Cell Analysis

Substances

Biomarkers, Tumor