Cytokine Blood Filtration Responses in COVID-19

Blood Purif. 2021;50(2):141-149. doi: 10.1159/000508278. Epub 2020 May 28.

Abstract

The real issue with the COVID-19 pandemic is that a rapidly increasing number of patients with life-threatening complications are admitted in hospitals and are not well-administered. Although a limited number of patients use the intensive care unit (ICU), they consume medical resources, safety equipment, and enormous equipment with little possibility of rapid recovery and ICU discharge. This work reviews effective methods of using filtration devices in treatment to reduce the level of various inflammatory mediators and discharge patients from the ICU faster. Extracorporeal technologies have been reviewed as a medical approach to absorb cytokines. Although these devices do not kill or remove the virus, they are a promising solution for treating patients and their faster removal from the ICU, thus relieving the bottleneck.

Keywords: Blood filtration devices; COVID-19; Coronavirus; Cytokine adsorption; Membranes.

Publication types

  • Review

MeSH terms

  • Acute Kidney Injury / etiology
  • Acute Kidney Injury / therapy
  • Anti-Bacterial Agents / therapeutic use
  • COVID-19 / blood
  • COVID-19 / complications*
  • Coated Materials, Biocompatible
  • Combined Modality Therapy
  • Continuous Renal Replacement Therapy
  • Cross-Over Studies
  • Cytokine Release Syndrome / blood
  • Cytokine Release Syndrome / etiology
  • Cytokine Release Syndrome / therapy*
  • Cytokines / blood*
  • Double-Blind Method
  • Equipment Design
  • Hemofiltration / instrumentation
  • Hemofiltration / methods*
  • Humans
  • Membranes, Artificial
  • Microspheres
  • Multiple Organ Failure / etiology
  • Multiple Organ Failure / therapy
  • Plasmapheresis / methods
  • Randomized Controlled Trials as Topic
  • Respiration, Artificial
  • Respiratory Distress Syndrome / etiology
  • Respiratory Distress Syndrome / therapy
  • SARS-CoV-2*
  • Shock, Septic / blood
  • Shock, Septic / etiology
  • Shock, Septic / therapy*
  • Sorption Detoxification / instrumentation
  • Sorption Detoxification / methods*

Substances

  • Anti-Bacterial Agents
  • Coated Materials, Biocompatible
  • Cytokines
  • Membranes, Artificial