Increasing production and utilization of cerium oxide nanoparticles (CNPs) in recent years have raised wide concerns about their toxicity. Numerous studies have been conducted to reveal the toxicity of CNPs, but the results are sometimes contradictory. In this review, the most important factors in mediating CNPs toxicity are discussed, including (1) the roles of physicochemical properties (size, morphology, agglomeration condition, surface charge, coating and surface valence state) on CNPs toxicity; (2) the phase transfer and transformation process of CNPs in various aqueous, terrestrial, and airborne environments; and (3) reductive dissolution of CNPs core and their chemical reactions with phosphate, sulfate/S2-, and ferrous ions. The physicochemical properties play key roles in the interactions of CNPs with organisms and consequently their environmental transformations, reactivity and toxicity assessment. Also, the speciation transformations of CNPs caused by reactions with (in)organic ligands in both environmental and biological systems would further alter their fate, transport, and toxicity potential. Thus, the toxicity mechanisms are proposed based on the physical damage of direct adsorption of CNPs onto the cell membrane and chemical inhibition (including oxidative stress and interaction of CNPs with biomacromolecules). Finally, the current knowledge gaps and further research needs in identifying the toxicological risk factors of CNPs under realistic environmental conditions are highlighted, which might improve predictions about their potential environmental influences. This review aims to provide new insights into cost-effectiveness of control options and management practices to prevent environmental risks from CNPs exposure.
Keywords: Cerium oxide nanoparticles; Environmental transformation; Redox reactions; Surface properties; Toxicity.