The damage caused by glaucoma has been extensively evaluated at the level of the retina and optic nerve head. Many advances have been shown in this field in the last decades. Recent studies have also proved degenerative changes in the brain involving the intracranial optic nerve, lateral geniculate nucleus, and visual cortex. Moreover, these brain abnormalities are also correlated with clinical, optic nerve head, and visual field findings. In this review, we critically evaluate the existing literature studying the use of magnetic resonance imaging in glaucoma, and we discuss issues related to how magnetic resonance imaging results should be incorporated into our clinical practice.