IBD Microbial Metabolome: The Good, Bad, and Unknown

Ashley M Sidebottom; Eugene B Chang

doi:10.1016/j.tem.2020.05.001

IBD Microbial Metabolome: The Good, Bad, and Unknown

Trends Endocrinol Metab. 2020 Nov;31(11):807-809. doi: 10.1016/j.tem.2020.05.001. Epub 2020 May 23.

Authors

Ashley M Sidebottom¹, Eugene B Chang²

Affiliations

¹ Department of Medicine, University of Chicago, Chicago, IL, USA.
² Department of Medicine, University of Chicago, Chicago, IL, USA. Electronic address: echang@medicine.bsd.uchicago.edu.

PMID: 32456844
DOI: 10.1016/j.tem.2020.05.001

Abstract

Gut microbiota shape the metabolome which then directly impacts host physiology. Sinha et al. observe and suggest that decreases in the levels of Ruminococcaceae and secondary bile acids (SBAs) contribute to pouchitis in ulcerative colitis (UC) patients with ileal pouch anal anastomosis (IPAA), raising the possibility of using SBAs as a preventative measure.

MeSH terms

Adult
Colitis, Ulcerative / microbiology*
Female
Gastrointestinal Microbiome / physiology
Humans
Male
Metabolome / genetics
Metabolome / physiology
Proctocolectomy, Restorative
Ruminococcus / genetics*