Every year millions of Muslims observe fasting during the month of Ramadan. Abstaining from drink and food for a long period may affect the physiology of the body, pathology of diseases, and pharmacokinetics/ pharmacodynamics of medicines. Health professionals should assess the suitability of patients to observe fasting without compromising their health. Pharmacists can contribute by recommending alternative medicine, dosage form, route of administration, dosing regimen, educating patients on balanced diets and proper use of their medicines, as well as monitoring of the clinical outcomes. This article aims to familiarize the readers with the practice of Ramadan fasting and various aspects regarding drug therapy and Ramadan fasting.