Gastroesophageal reflux disease: prevalence and Extraesophageal manifestations among undergraduate students in South West Nigeria

BMC Gastroenterol. 2020 May 26;20(1):160. doi: 10.1186/s12876-020-01292-1.

Abstract

Background: The reflux of noxious contents of the stomach may cause oesophageal and extra-oesophageal complications either by direct contact of aspirated gastric refluxate with the upper airway or by a vago-vagal reflex. This study aimed to determine the prevalence of gastroesophageal disease (GERD) and extraesophageal manifestations among undergraduate students in a tertiary institution in Nigeria.

Methods: This is a cross-sectional study involving undergraduate students in a private University in Nigeria. Study proforma had three parts. Part A consisted of self-administered questionnaire designed to obtain students biodata. Part B consisted of standard Carlsson-Dent questionnaire. A score of 4 and above on Carlsson- Dent questionnaire was considered diagnostic of gastroesophageal reflux symptoms (GERD). Thereafter those who had GERD were further questioned and examined for extra-oesophageal symptoms of GERD.

Results: The total number of the study participants was 647, out of which 212 (32.8%) had GERD. One hundred and forty-four (67.9%) and 86 (32.1%) females and male had GERD respectively (p = 0.13). The extraesophageal symptoms found in those with GERD were, dysphagia, coated tongue, nocturnal cough, xerostomia, lump in the throat, asthma-like symptoms, recurrent sore throat, frequent throat clearing, halithosis and dental erosion among others.

Conclusion: GERD is common among this study population, with a prevalence rate of 32.8%. Only age showed significant predictor for GERD. Varying extra-oesophageal manifestations were found in those with GERD.

Keywords: Dental erosion; Gastroesophageal reflux extraesophageal disease; Halitosis; Nocturnal cough.

MeSH terms

  • Adolescent
  • Asthma / epidemiology
  • Asthma / etiology
  • Cough / epidemiology
  • Cough / etiology
  • Cross-Sectional Studies
  • Deglutition Disorders / epidemiology
  • Deglutition Disorders / etiology
  • Female
  • Gastroesophageal Reflux / complications*
  • Gastroesophageal Reflux / epidemiology*
  • Halitosis / epidemiology
  • Halitosis / etiology
  • Humans
  • Male
  • Nigeria / epidemiology
  • Pharyngitis / epidemiology
  • Pharyngitis / etiology
  • Prevalence
  • Students / statistics & numerical data*
  • Surveys and Questionnaires
  • Tongue Diseases / epidemiology
  • Tongue Diseases / etiology
  • Tooth Erosion / epidemiology
  • Tooth Erosion / etiology
  • Xerostomia / epidemiology
  • Xerostomia / etiology
  • Young Adult