Battling COVID-19: using old weapons for a new enemy

Rohit Kumar; Nitin Gupta; Parul Kodan; Ankit Mittal; Manish Soneja; Naveet Wig

doi:10.1186/s40794-020-00107-1

Battling COVID-19: using old weapons for a new enemy

Trop Dis Travel Med Vaccines. 2020 May 20:6:6. doi: 10.1186/s40794-020-00107-1. eCollection 2020.

Authors

Rohit Kumar¹, Nitin Gupta², Parul Kodan³, Ankit Mittal¹, Manish Soneja¹, Naveet Wig¹

Affiliations

¹ 1Department of Medicine, All India Institute of Medical Sciences, New Delhi, 110029 India.
² 2Department of Infectious Diseases, Kasturba Medical College, Manipal, Karnataka 576104 India.
³ 3Dr Ram Manohar Lohia hospital & Post-Graduate Institute of Medica education and Research, New Delhi, 110001 India.

Abstract

Coronavirus disease-19 (COVID-19) has reached pandemic proportions. Most of the drugs that are being tried for the treatment have not been evaluated in any randomized controlled trials. The purpose of this review was to summarize the in-vitro and in-vivo efficacy of these drugs on Severe Acute Respiratory Syndrome (SARS-CoV-2) and related viruses (SARS and Middle East Respiratory Syndrome) and evaluate their potential for re-purposing them in the management of COVID-19.

Keywords: Hydroxychloroquine; Lopinavir/ritonavir; Nitazoxanide; Remdisivir; SARS-CoV-2; Tocilizumab.

Publication types

Review