A Systematic Review of the Mechanisms Underlying Treatment of Gastric Precancerous Lesions by Traditional Chinese Medicine

Liangjun Yang; Jiali Li; Zhipeng Hu; Xiangzhen Fan; Tiantian Cai; Hengli Zhou; Huafeng Pan

doi:10.1155/2020/9154738

A Systematic Review of the Mechanisms Underlying Treatment of Gastric Precancerous Lesions by Traditional Chinese Medicine

Evid Based Complement Alternat Med. 2020 Apr 26:2020:9154738. doi: 10.1155/2020/9154738. eCollection 2020.

Authors

Liangjun Yang^{1

2}, Jiali Li², Zhipeng Hu³, Xiangzhen Fan², Tiantian Cai⁴, Hengli Zhou², Huafeng Pan²

Affiliations

¹ Department of Gastroenterology, Tongde Hospital of Zhejiang Province, Hangzhou 310012, China.
² Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
³ The Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
⁴ The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510000, China.

Abstract

Gastric precancerous lesions (GPLs) are an essential precursor in the occurrence and development of gastric cancer, known to be one of the most common and lethal cancers worldwide. Traditional Chinese medicine (TCM) has a positive prospect for the prevention and therapy of GPL owing to several advantages including a definite curative effect, fewer side effects compared to other treatments, multiple components, and holistic regulation. Despite these characteristic advantages, the mechanisms of TCM in treating GPL have not been fully elucidated. In this review, we summarize the current knowledge with respect to herbal formulations and the therapeutic mechanisms of TCM active ingredients for GPL. This paper elaborates on the mechanisms of TCM underlying the prevention and treatment of GPL, specifically those that are linked to anti-H. pylori, anti-inflammation, antiproliferation, proapoptotic, antioxidation, antiglycolytic, and antiangiogenesis effects.

Publication types

Review