Antiparasitic, anti-inflammatory and cytotoxic activities of 2D coordination polymers based on 1H-indazole-5-carboxylic acid

Antonio A García-Valdivia; Amalia García-García; Fatin Jannus; Andoni Zabala-Lekuona; José M Méndez-Arriaga; Belén Fernández; Marta Medina-O'donnell; Gloria B Ramírez-Rodríguez; José M Delgado-López; Luisa M Pastrana-Martínez; Javier Cepeda; José A Lupiáñez; Fernando J Reyes-Zurita; Antonio Rodríguez-Diéguez

doi:10.1016/j.jinorgbio.2020.111098

Antiparasitic, anti-inflammatory and cytotoxic activities of 2D coordination polymers based on 1H-indazole-5-carboxylic acid

J Inorg Biochem. 2020 Jul:208:111098. doi: 10.1016/j.jinorgbio.2020.111098. Epub 2020 May 18.

Authors

Affiliations

¹ Departamento de Química Inorgánica, Facultad de Ciencias, Universidad de Granada, Av. Fuentenueva s/n, 18071 Granada, Spain.
² Departamento de Bioquímica y Biología Molecular I, Facultad de Ciencias, Universidad de Granada, Av. Fuentenueva s/n, 18071 Granada, Spain.
³ Departamento de Química Aplicada, Facultad de Química, Universidad del País Vasco (UPV/EHU), Paseo Manuel Lardizabal, no 3, 20018 Donostia-San Sebastián, Spain.
⁴ Department of Biology and Geology, Physics and Inorganic Chemistry, Calle Tulipán s/n, 28933 Móstoles, Madrid, Spain.
⁵ Institute of Parasitology and Biomedicine "López-Neyra", CSIC, Av. Conocimiento s/n, 18600 Granada, Spain. Electronic address: belenfernandez@ipb.csic.es.
⁶ Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Granada, Av. Fuentenueva s/n, 18071 Granada, Spain.
⁷ Departamento de Bioquímica y Biología Molecular I, Facultad de Ciencias, Universidad de Granada, Av. Fuentenueva s/n, 18071 Granada, Spain. Electronic address: ferjes@ugr.es.
⁸ Departamento de Química Inorgánica, Facultad de Ciencias, Universidad de Granada, Av. Fuentenueva s/n, 18071 Granada, Spain. Electronic address: antonio5@ugr.es.

PMID: 32454248
DOI: 10.1016/j.jinorgbio.2020.111098

Abstract

We report on the formation of two novel multifunctional isomorphous (4,4) square-grid 2D coordination polymers based on 1H-indazole-5-carboxylic acid. To the best of our knowledge, these complexes are the first examples of 2D-coordination polymers constructed with this novel ligand. We have analysed in detail the structural, magnetic and anti-parasitic properties of the resulting materials. In addition, the capability of inhibiting nitric oxide production from macrophage cells has been measured and was used as an indirect measure of the anti-inflammatory response. Finally, the photocatalytic activity was measured with a model pollutant, i.e. vanillic acid (phenolic compound), with the aim of further increasing the functionalities and applicability of the compounds.

Keywords: 1H-indazole-5-carboxylic acid; Anti-inflammatory; Anticancer activity; Antiparasitic; Coordination polymers.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Inflammatory Agents* / chemical synthesis
Anti-Inflammatory Agents* / chemistry
Anti-Inflammatory Agents* / pharmacology
Antiprotozoal Agents* / chemical synthesis
Antiprotozoal Agents* / chemistry
Antiprotozoal Agents* / pharmacology
Coordination Complexes* / chemical synthesis
Coordination Complexes* / chemistry
Coordination Complexes* / pharmacology
Cytotoxins* / chemical synthesis
Cytotoxins* / chemistry
Cytotoxins* / pharmacology
Indazoles* / chemistry
Indazoles* / pharmacology
Leishmania / growth & development*
Mice
RAW 264.7 Cells

Substances

Anti-Inflammatory Agents
Antiprotozoal Agents
Coordination Complexes
Cytotoxins
Indazoles