Severe Rifampicin-induced Vitamin K Deficiency Coagulopathy in a Child

Pediatr Infect Dis J. 2020 Sep;39(9):833-834. doi: 10.1097/INF.0000000000002728.

Abstract

An 8-month-old child under tuberculosis treatment presented with multiple ecchymotic lesions. A severe coagulopathy was evidenced compatible with vitamin K deficiency [II (3%), VII (2%), IX (3%) and X (1%)]. It was reversed with vitamin K and plasma administration. Rifampicin-induced vitamin K deficiency is very rare, reported only once before, possibly related to an inhibition of vitamin K cycle.

Publication types

  • Case Reports

MeSH terms

  • Antibiotics, Antitubercular / adverse effects*
  • Blood Coagulation Disorders / chemically induced*
  • Blood Coagulation Disorders / diagnosis*
  • Blood Coagulation Disorders / drug therapy
  • Blood Coagulation Disorders / therapy
  • Child
  • Humans
  • Infant
  • Male
  • Plasma
  • Rifampin / adverse effects*
  • Treatment Outcome
  • Tuberculosis / drug therapy
  • Vitamin K / administration & dosage
  • Vitamin K Deficiency / complications*
  • Vitamin K Deficiency / etiology

Substances

  • Antibiotics, Antitubercular
  • Vitamin K
  • Rifampin