New meroterpenoids and C-methylated flavonoid isolated from Baeckea frutescens

Chin J Nat Med. 2020 May;18(5):379-384. doi: 10.1016/S1875-5364(20)30044-3.

Abstract

Phytochemical investigation of the aerial parts of Baeckea frutescens resulted in the isolation of three new mono- or sesquiterpene-based meroterpenoids, frutescones S-U (1-3), and one pair of new (±)-5,7-dihydroxy-8-isobutyryl-6-methyldihydroflavonol (4). Their structures and absolute configurations were established by HR-ESI-MS, 1D and 2D NMR, and quantum chemical ECD calculation. Compound 1 exhibited inhibitory effect on NO production in LPS-activated RAW 264.7 macrophages with an IC50 value being 0.81 μmol·L-1.

Keywords: Anti-inflammatory; Baeckea frutescens; Meroterpenoid; Myrtaceae.

MeSH terms

  • Animals
  • Drugs, Chinese Herbal / chemistry*
  • Drugs, Chinese Herbal / isolation & purification
  • Drugs, Chinese Herbal / pharmacology
  • Flavonoids / chemistry*
  • Flavonoids / isolation & purification
  • Flavonoids / pharmacology
  • Mass Spectrometry
  • Mice
  • Molecular Structure
  • Myrtaceae / chemistry*
  • Plant Components, Aerial / chemistry
  • RAW 264.7 Cells
  • Terpenes / chemistry*
  • Terpenes / isolation & purification
  • Terpenes / pharmacology

Substances

  • Drugs, Chinese Herbal
  • Flavonoids
  • Terpenes