Objective: To evaluate the sleep status and the correlation of sleep status with inflammatory bowel disease (IBD). Methods: A case-control study was carried out, including 568 IBD patients including 188 ucerative colitis (UC) patients and 380 Crohn's disease (CD) patients at 36 hospitals from January 1, 2018 to August 31, 2019, and 671 family members and healthy controls from the same cities. The survey consisted of three parts including general demographic data, clinical characteristics and sleep related factors by questionnaires. The items for sleep related factor included sleep duration on work days, sleep duration on weekends, sleep quality, sleep adequacy, snoring, sleep apnea and sleep hand foot movement. R language was used for propensity score and SPSS was used for statistical analysis. Results: The proportion of poor sleep quality before onset in UC and CD was higher than that in healthy control group (CD: 14.5% vs 5.3%, P<0.001; UC: 15.1% vs 5.4%, P<0.001). In CD group, the proportion of snoring before onset (31.3% vs 44.3%, P<0.001) and apnea (0.9% vs 5.5%, P=0.001) was lower than that in heathy control group. The proportion of athetosis in CD was higher than that in healthy control group (35.4% vs 28.9%, P=0.045). Conclusion: Patients with UC and CD have poor sleep quality before the onset of the disease, especially in CD patients.
目的： 评估炎症性肠病（IBD）患者睡眠状况及相互关系。 方法： 采用病例对照研究，纳入2018年1月1日至2019年8月31日36所医院收治568例IBD患者作为病例组，其中溃疡性结肠炎（UC）188例，克罗恩病（CD）380例，同时纳入患者家属及同城健康人群671名作为对照组。收集所有研究对象一般人口学资料、疾病相关、睡眠因素相关的问卷调查（包括工作日睡眠时长、周末睡眠时长、睡眠质量、睡眠充足与否、打鼾、睡眠呼吸暂停、睡眠手足徐动调查）。使用R语言进行倾向性评分，使用SPSS进行统计学分析。 结果： UC组和CD组在起病前睡眠质量差的比例高于健康对照组，差异有统计学意义（CD组：14.5%比5.3%，P<0.001；UC组：15.1%比5.4%，P<0.001）；CD组起病前打鼾（31.3%比44.3%，P<0.001）和呼吸暂停（0.9%比5.5%，P=0.001）的比例低于对照组，手足徐动的比例高于对照组（35.4%比28.9%，P=0.045）。 结论： UC和CD患者在起病前便出现睡眠质量差的情况，CD患者睡眠改变尤为明显。.
Keywords: Colitis, ulcerative; Crohn disease; Propensity score; Sleep.