Role of non-coding RNAs as novel biomarkers for detection of colorectal cancer progression through interaction with the cell signaling pathways

Gene. 2020 Aug 30:753:144796. doi: 10.1016/j.gene.2020.144796. Epub 2020 May 22.

Abstract

Colorectal cancer (CRC) is one of the most common types of cancer which affects the colon and the rectum. Approximately one third of annual CRC mortality occurs due to the late detection of this type of cancer. Therefore, there is an urgent need for more powerful diagnostic and prognostic tools for identification and treatment of colorectal tumorigenesis. Non-coding RNAs (ncRNAs) have been implicated in the pathology of CRC and also linked to metastasis, proliferation, differentiation, migration, angiogenesis and apoptosis in numerous cancers. Recently, attention has turned towards ncRNAs as specific targets for diagnosis, prognosis and treatment of various types of cancers, including CRC. In this review, we have tried to outline the roles of ncRNAs, and their involvement in signaling pathways responsible for the progression of CRC.

Keywords: Circular RNA; Colorectal cancer; Long non-coding RNA; Non-coding RNA; miRNA.

Publication types

  • Review

MeSH terms

  • Apoptosis / genetics
  • Biomarkers, Tumor / genetics*
  • Carcinogenesis / genetics
  • Cell Transformation, Neoplastic / genetics
  • Colorectal Neoplasms / diagnosis*
  • Colorectal Neoplasms / genetics*
  • Disease Progression
  • Gene Expression Regulation, Neoplastic / genetics
  • Humans
  • MicroRNAs / genetics
  • MicroRNAs / metabolism
  • Prognosis
  • RNA, Long Noncoding / genetics
  • RNA, Long Noncoding / metabolism
  • RNA, Neoplasm / genetics
  • RNA, Untranslated
  • Signal Transduction / genetics

Substances

  • Biomarkers, Tumor
  • MicroRNAs
  • RNA, Long Noncoding
  • RNA, Neoplasm
  • RNA, Untranslated