We show that readily available α-amidoaldehydes are effective substrates for intermolecular Rh-catalyzed alkyne hydroacylation reactions. The catalyst [Rh(dppe)(C6 H5 F)][BArF 4 ] provides good reactivity, and allows a broad range of aldehydes and alkynes to be used as substrates, delivering α-amidoketone products. High yields and high levels of regioselectivity are achieved. The use of α-amidoaldehydes as substrates establishes that 1,4-dicarbonyl motifs can be used as controlling groups in Rh-catalyzed hydroacylation reactions.
Keywords: aldehyde; alkyne; catalysis; hydroacylation; rhodium.
© 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.